DSIP 2MG

Delta-sleep-inducing peptide is a neuropeptide that affects a number of endocrine and physiological processes within the central nervous system. DSIP is of primary interest for its abilities to reduce oxidative stress, normalize myocardial contractility. It is also being studied as a potential target in the treatment of major depressive disorder. 

DSIP is a synthetic analogue of a naturally occurring nonapeptide primarily produced in the cerebrospinal fluid during sleep in mammals1, though the peptide has been found in the hypothalamus, the pituitary, and adrenal glands2. Adminstration of DSIP has been shown to induce sleep or to correct dysfunctional (i.e. narcoleptic) sleeping patterns in animal subjects, hence the DSIP acronym representing ‘Delta-Sleep Inducing Hormone3’. This neuropeptide has also been shown to reduce chronic pain4, alleviate withdrawal symptoms in opiate and alcohol dependent subjects5, and to reduce the symptomatic severity of major depressive disorder6.

Through extensive research, it has been shown that DSIP is an extremely versatile peptide with important roles throughout mammalian systems. It has been demonstrated that DSIP is a potent endrocine regulator with specific action in the inhibition of somatostatin secretion, which led to enhanced secretion of growth hormone (GH) and enhanced muscle growth in animal trials7. DSIP has also proven to be an effective alleviator of stress, reducer of blood pressure, and normalizer of irregular heart impulses8.

Anti-Oxidant Benefits

DSIP also plays a role in preventing serious pathologies through its action as a stimulator of oxidative phosphorylation, thereby inducing anti-oxidative effects throughout mammalian systems9. Anti-oxidising agents have been demonstrated as potent defenses against spontaneous tumour generation10, preventing various cancers caused by free radical associated genetic damage. Via the same mechanism, DSIP shows great potential as a defense against age-related pathologies11, working to clear the body of free radicals when senescent immune systems prove insufficient.

Synonyms:

Delta sleep inducing peptide; Phosphorylated delta sleep inducing peptide; DSIP;